Thirty-two Harvard Ophthalmology/Mass. Eye and Ear clinical trainees graduated on Thursday, June 20th. The ceremony celebrated eight Harvard Ophthalmology residents, the AY 2018–2019 Chief Resident and one optometry resident, as well as 22 clinical fellows from Mass. Eye and Ear, Joslin Diabetes Center and Boston Children’s Hospital.... Read more about 2019 Trainee Graduation
New research led by Kip Connor, PhD, finds that microglia—the primary immune cells of the central nervous system, including the retina—play a vital role in regulating neuroinflammation in autoimmune uveitis. The study, published in Proceedings of the National Academy of Sciences and featured on eyewire News, may one day lead to better treatment targets for the disease.
In the preclinical model of autoimmune uveitis, the researchers describe, for the first time, a role for microglia in directing the initiation of autoimmune uveitis by orchestrating the inflammatory response within the retina. In reaction to disease induction, microglia closely associate with the retinal vasculature and facilitate inflammatory immune cell entry past the blood brain, or ocular, barrier into the retina. When the researchers depleted microglia in this model, they observed that the disease was completely blocked.