A study led by Eleftherios Paschalis, PhD, describes a mechanism by which patients with acute ocular injuries become susceptible to progressive neurodegeneration long after the injury has taken place. Published in Proceedings of National Academy of Sciences, Dr. Paschalis and colleagues demonstrate that immune cells from the periphery infiltrate the retina after acute injury and contribute to progressive loss of retina ganglion cells. These peripheral cells become engrafted into the retina and remain in a persistent reactive inflammatory state, contributing to disease long after the initial injury. These findings may have therapeutic implications for progressive neuroretinal diseases where inflammation is a significant player.
November 19, 2018