Researchers Identify Metabolomics as a Potential Tool to Improve Diagnostic and Prognostic Information on AMD

July 9, 2019

A recent meta-analysis, led by Deeba Husain, MD, suggests that AMD patients present distinct plasma metabolomic profiles, which vary with disease severity. After analyzing blood samples of their 491 patients from two cohorts–one in Boston and one in Coimbra, Portugal–they found that metabolites differed significantly between AMD patients as compared to controls, and with various stages of the disease.

Pathway analysis also showed significant alterations of certain lipid and amino acids metabolism across patients with varying stages of AMD. These findings, published in Metabolites, suggest that metabolomics may help understand disease pathogenesis, serve as potential future biomarkers, and facilitate the development of precision medicine for AMD.