NIR-Triggered Drug Delivery by Collagen-Mediated Second Harmonic Generation.
Publication information:
Barhoumi A, Salvador-Culla B, Kohane D. NIR-Triggered Drug Delivery by Collagen-Mediated Second Harmonic Generation.
Adv Healthc Mater. 2015;4(8):1159–63. PMID: 25728310
Abstract
Second harmonic generation is a process through which nonlinear materials such as collagen can absorb two photons and scatter one with twice the energy. Collagen upconverts 730 nm (near-IR) to 365 nm (UV) through second harmonic generation, which cleaves a molecule bound to collagen via a UV-sensitive linker.