Outcome of cataract surgery in patients with retinitis pigmentosa


Nguyen X-T-A, Thiadens AAHJ, Fiocco M, Tan W, McKibbin M, Klaver CCCW, Meester-Smoor MA, Van Cauwenbergh C, Strubbe I, Vergaro A, Pott J-WR, Hoyng CB, Leroy BP, Zemaitiene R, Khan KN, Boon CJF. Outcome of cataract surgery in patients with retinitis pigmentosa. Am J Ophthalmol 2022;

Date Published:

2022 Oct 14


PURPOSE: To assess the visual outcome of cataract surgery in patients with retinitis pigmentosa (RP). DESIGN: Retrospective, non-comparative clinical study. METHODS: Preoperative, intraoperative and postoperative data of patients with RP undergoing cataract surgery were collected from several expertise centers across Europe. RESULTS: In total, 295 eyes of 225 patients were included in the study. The mean age at surgery of the first eye was 56.1 ± 17.9 years. Following surgery, best-corrected visual acuity (BCVA) improved significantly from 1.03 to 0.81 logMAR (i.e. 20/214 to 20/129 Snellen) in the first treated eye (-0.22 logMAR; 95% CI: -0.31 to -0.13; p < 0.001), and from 0.80 to 0.56 logMAR (i.e. 20/126 to 20/73 Snellen) in the second treated eye (-0.24 logMAR; 95% CI: -0.32 to -0.15; p < 0.001). Marked BCVA improvements (postoperative change in BCVA of ≥ 0.3 logMAR) were observed in 87 out of 226 patients (39%). Greater odds for marked visual improvements were observed in patients with moderate visual impairment or worse. The most common complications were zonular dialysis (n = 15; 5%), and (exacerbation of) cystoid macular edema (n = 14; 5%), respectively. Postoperative posterior capsular opacifications were present in 111 out of 295 (38%) eyes. CONCLUSION: Significant improvements in BCVA are observed in most patients with RP following cataract surgery. Baseline BCVA is a predictor for visual outcome. Preoperative evaluation should include the assessment of potential zonular insufficiency and the presence of CME, as they are relatively common, and may increase the risk for complications.

Last updated on 10/29/2022