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Deep Learning of the Retina Enables Phenome- and Genome-Wide Analyses of the Microvasculature

Journal Article

BACKGROUND: The microvasculature, the smallest blood vessels in the body, has key roles in maintenance of organ health and tumorigenesis. The retinal fundus is a window for human in vivo noninvasive assessment of the microvasculature. Large-scale...

Complete Genome Sequence of Linezolid-Susceptible Staphylococcus haemolyticus Sh29/312/L2, a Clonal Derivative of a Linezolid-Resistant Clinical Strain.

Journal Article

We report the whole-genome sequence (WGS) of an in vitro susceptible derivative revertant mutant from a bloodstream isolate involved in a nosocomial outbreak in Brazil. The WGS comprises 2.5 Mb with 2,500 protein-coding sequences, 16rRNA genes, and 60...

Genome-wide association meta-analysis for early age-related macular degeneration highlights novel loci and insights for advanced disease

Journal Article

BACKGROUND: Advanced age-related macular degeneration (AMD) is a leading cause of blindness. While around half of the genetic contribution to advanced AMD has been uncovered, little is known about the genetic architecture of early AMD. METHODS: To...

Genome editing with CRISPR-Cas9 prevents angiogenesis of the retina

News

Powerful new technology may lead to novel therapies to prevent vision loss, blindness in those with diseases of the retina Boston, Mass. — A research team from the Schepens Eye Research Institute of Massachusetts Eye and Ear has successfully prevented...

Genome-wide screen for genes involved in eDNA release during biofilm formation by Staphylococcus aureus

Journal Article

Staphylococcus aureus is a leading cause of both nosocomial and community-acquired infection. Biofilm formation at the site of infection reduces antimicrobial susceptibility and can lead to chronic infection. During biofilm formation, a subset of cells...

Genome-wide association study of primary open-angle glaucoma in continental and admixed African populations

Journal Article

Primary open angle glaucoma (POAG) is a complex disease with a major genetic contribution. Its prevalence varies greatly among ethnic groups, and is up to five times more frequent in black African populations compared to Europeans. So far, worldwide...

A multi-cohort genome-wide association study in African ancestry individuals reveals risk loci for primary open-angle glaucoma

Journal Article

Primary open-angle glaucoma (POAG), the leading cause of irreversible blindness worldwide, disproportionately affects individuals of African ancestry. We conducted a genome-wide association study (GWAS) for POAG in 11,275 individuals of African ancestry...

Large-scale multitrait genome-wide association analyses identify hundreds of glaucoma risk loci

Journal Article

Glaucoma, a leading cause of irreversible blindness, is a highly heritable human disease. Previous genome-wide association studies have identified over 100 loci for the most common form, primary open-angle glaucoma. Two key glaucoma-associated traits also...

Identification of Padi2 as a novel angiogenesis-regulating gene by genome association studies in mice

Journal Article

Recent findings indicate that growth factor-driven angiogenesis is markedly influenced by genetic variation. This variation in angiogenic responsiveness may alter the susceptibility to a number of angiogenesis-dependent diseases. Here, we utilized the...

Perspectives of Rare Disease Experts on Newborn Genome Sequencing

Journal Article

IMPORTANCE: Newborn genome sequencing (NBSeq) can detect infants at risk for treatable disorders currently undetected by conventional newborn screening. Despite broad stakeholder support for NBSeq, the perspectives of rare disease experts regarding which...

Genome-wide identification and characterization of functional neuronal activity-dependent enhancers.

Journal Article

Experience-dependent gene transcription is required for nervous system development and function. However, the DNA regulatory elements that control this program of gene expression are not well defined. Here we characterize the enhancers that function...

Genome-Wide Association Study Identifies a Susceptibility Locus for Comitant Esotropia and Suggests a Parent-of-Origin Effect

Journal Article

Purpose: To identify genetic variants conferring susceptibility to esotropia. Esotropia is the most common form of comitant strabismus, has its highest incidence in European ancestry populations, and is believed to be inherited as a complex trait. Methods...

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351 results for "Genomics"

351 results for "Genomics"

Deep Learning of the Retina Enables Phenome- and Genome-Wide Analyses of the Microvasculature

Complete Genome Sequence of Linezolid-Susceptible Staphylococcus haemolyticus Sh29/312/L2, a Clonal Derivative of a Linezolid-Resistant Clinical Strain.

Genome-wide association meta-analysis for early age-related macular degeneration highlights novel loci and insights for advanced disease

Genome editing with CRISPR-Cas9 prevents angiogenesis of the retina

Genome-wide screen for genes involved in eDNA release during biofilm formation by Staphylococcus aureus

Genome-wide association study of primary open-angle glaucoma in continental and admixed African populations

A multi-cohort genome-wide association study in African ancestry individuals reveals risk loci for primary open-angle glaucoma

Large-scale multitrait genome-wide association analyses identify hundreds of glaucoma risk loci

Identification of Padi2 as a novel angiogenesis-regulating gene by genome association studies in mice

Perspectives of Rare Disease Experts on Newborn Genome Sequencing

Genome-wide identification and characterization of functional neuronal activity-dependent enhancers.

Genome-Wide Association Study Identifies a Susceptibility Locus for Comitant Esotropia and Suggests a Parent-of-Origin Effect