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Berman-Gund Laboratory for the Study of Retinal Degenerations

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Image: Cone photoreceptors of the human retina. From the Human Retina Collection, Dr. Ann Milam Director Eric A. Pierce, MD, PhD Investigators View list of retinal degeneration faculty Inherited retinal degenerations (IRDs) like retinitis pigmentosa are...

Disparities in Inherited Retinal Degenerations

Journal Article

To review disparities in the field of inherited retinal degenerations to establish foundations for future discussions oriented toward finding possible solutions. A narrative overview of the literature. Despite collective efforts towards democratization of...

Oxidative stress in retinal pigment epithelium degeneration: from pathogenesis to therapeutic targets in dry age-related macular degeneration

Journal Article

Age-related macular degeneration is a primary cause of blindness in the older adult population. Past decades of research in the pathophysiology of the disease have resulted in breakthroughs in the form of anti-vascular endothelial growth factor therapies...

Nr2e3 is a genetic modifier that rescues retinal degeneration and promotes homeostasis in multiple models of retinitis pigmentosa

Journal Article

Recent advances in viral vector engineering, as well as an increased understanding of the cellular and molecular mechanism of retinal diseases, have led to the development of novel gene therapy approaches. Furthermore, ease of accessibility and ocular...

Preclinical dose response study shows NR2E3 can attenuate retinal degeneration in the retinitis pigmentosa mouse model Rho

Journal Article

Retinitis pigmentosa (RP) is a heterogeneous disease and the main cause of vision loss within the group of inherited retinal diseases (IRDs). IRDs are a group of rare disorders caused by mutations in one or more of over 280 genes which ultimately result...

Ift172 conditional knock-out mice exhibit rapid retinal degeneration and protein trafficking defects

Journal Article

Intraflagellar transport (IFT) is a bidirectional transport process that occurs along primary cilia and specialized sensory cilia, such as photoreceptor outersegments. Genes coding for various IFT components are associated with ciliopathies. Mutations in...

Retinal degeneration induced in a mouse model of ischemia-reperfusion injury and its management by pemafibrate treatment

Journal Article

Retinal ischemia-reperfusion (I/R) injury is a common cause of visual impairment. To date, no effective treatment is available for retinal I/R injury. In addition, the precise pathological mechanisms still need to be established. Recently, pemafibrate, a...

Müller glial responses compensate for degenerating photoreceptors in retinitis pigmentosa

Journal Article

Photoreceptor degeneration caused by genetic defects leads to retinitis pigmentosa, a rare disease typically diagnosed in adolescents and young adults. In most cases, rod loss occurs first, followed by cone loss as well as altered function in cells...

Correlation of cytokine levels and microglial cell infiltration during retinal degeneration in RCS rats

Journal Article

Microglial cells, which are immunocompetent cells, are involved in all diseases of the central nervous system. During their activation in various diseases, a variety of soluble factors are released. In the present study, the correlation between cytokine...

Statement regarding first in-human clinical trial in inherited retinal degeneration (retinitis pigmentosa)

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Mass. Eye and Ear and the Harvard Medical School Department of Ophthalmology are proud to be leading this important clinical trial. We look forward to reporting on safety and efficacy studies in the months and years to come. ReNeuron announces first...

Visual Contrast Sensitivity Correlates to the Retinal Degeneration in Rhodopsin Knockout Mice

Journal Article

Purpose: Clinical manifestations of photoreceptor degeneration include gradual thinning of the outer nuclear layer (ONL) and progressive reduction of electroretinogram (ERG) amplitudes and vision loss. Although preclinical evaluations of treatment...

Programmed necrosis, not apoptosis, is a key mediator of cell loss and DAMP-mediated inflammation in dsRNA-induced retinal degeneration

Journal Article

There is no known treatment for the dry form of an age-related macular degeneration (AMD). Cell death and inflammation are important biological processes thought to have central role in AMD. Here we show that receptor-interacting protein (RIP) kinase...