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Cornea Conference

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The Biennial Cornea Conference is the premier global anterior segment eye research conference and is designed to be a platform for presenting the current basic and clinical research in the field of cornea and ocular surface. 

Biomechanical characterization of keratoconus corneas ex vivo with Brillouin microscopy

Journal Article

PURPOSE: Loss of corneal strength is a central feature of keratoconus progression. However, it is currently difficult to measure corneal mechanical changes noninvasively. The objective of this study is to evaluate if Brillouin optical microscopy can...

Characterization of non-linear mechanical behavior of the cornea

Journal Article

The objective of this study was to evaluate which hyperelastic model could best describe the non-linear mechanical behavior of the cornea, in order to characterize the capability of the non-linear model parameters to discriminate structural changes in a...

Modeling the cornea in 3-dimensions: Current and future perspectives

Journal Article

The cornea is an avascular, transparent ocular tissue that serves as a refractive and protective structure for the eye. Over 90% of the cornea is composed of a collagenous-rich extracellular matrix within the stroma with the other 10% composed by the...

Jennifer Tran, MD, Receives Cornea and Refractive Surgery Research Award

News

Jennifer Tran, MD, is the 2024-2025 recipient of the Best Clinical Trainee Research Award in Cornea and Refractive Surgery. 

Nerves and neovessels inhibit each other in the cornea

Journal Article

PURPOSE: To evaluate the regulatory cross-talk of the vascular and neural networks in the cornea. METHODS: b-FGF micropellets (80 ng) were implanted in the temporal side of the cornea of healthy C57Bl/6 mice. On day 7, blood vessels (hemangiogenesis) and...

UV cross-linking of donor corneas confers resistance to keratolysis.

Journal Article

PURPOSE: The aim of this study was to develop a modified ex vivo corneal cross-linking method that increases stromal resistance to enzymatic degradation for use as a carrier for the Boston keratoprosthesis. METHODS: Ex vivo cross-linking of human corneas...

Age-related changes and diseases of the ocular surface and cornea

Journal Article

Aging of the ocular surface and corneal tissues, major components of the visual system, causes major eye disease and results in substantial cost in medical and social terms. These diseases include the highly prevalent dry eye disease that affects the...

Cornea Center of Excellence Hosts Cell Therapy Workshop

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The Harvard Ophthalmology Cornea Center of Excellence brought together faculty members on September 13 for a workshop on corneal cell therapy.

Cornea

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Center of Excellence Co-Directors Reza Dana, MD, MSc, MPH Ula V. Jurkunas, MD Members See a list of Cornea COE faculty The Cornea Center of Excellence brings together one of the world’s largest group of scientists and physicians to advance our...

Subconjunctival injection of mesenchymal stromal cells protects the cornea in an experimental model of GVHD

Journal Article

PURPOSE: To evaluate the therapeutic effect of subconjunctival injection of human mesenchymal stromal cells (hMSCs) in the cornea of mice with graft versus host disease (GVHD). METHODS: GVHD was induced in mice after hematopoietic stem cell...

The Chemokine Receptor CXCR4 Mediates Recruitment of CD11c+ Conventional Dendritic Cells Into the Inflamed Murine Cornea

Journal Article

Purpose: The cornea contains distinct populations of antigen-presenting cells (APCs), including conventional dendritic cells (cDCs). Little is known about the molecular mechanisms involved in cDCs homing and recruitment into the naïve and inflamed cornea...