Cornea

Researchers identify mechanism of retina damage following chemical eye burns

Researchers identify mechanism of retina damage following chemical eye burns

April 13, 2017

Findings may lead to the development of therapies to prevent damage to the retina, the light-sensitive tissue at the back of the eye.

Boston, Mass. — Chemical eye burns caused by alkali agents not only injure the front of the eye — the cornea, where the contact takes place —  but also cause widespread damage to the light-sensitive tissue at the back of the eye (the retina) as well, often leading to optic nerve damage and glaucoma. In a report...

Read more about Researchers identify mechanism of retina damage following chemical eye burns
Deborah Langston Becomes First to Receive Three Highest Honors in the Field of Cornea

Deborah Langston Becomes First to Receive Three Highest Honors in the Field of Cornea

October 14, 2016

Deborah Pavan-Langston, MD, FACS—Harvard Ophthalmology alumna and Professor Emeritus—received the Claes Dohlman Society Award at the Cornea Society/Eye Bank Association of America 2016 Fall Educational Symposium. This lifetime achievement award recognizes her excellence in teaching and contributions to the field of cornea and external disease. 

Dr. Langston is the first person to receive all three of the highest honors in cornea: the Castroviejo Medal for Outstanding Contributions to the Field of Corneal and Anterior Segment Disease (American Academy of Ophthalmology), the...

Read more about Deborah Langston Becomes First to Receive Three Highest Honors in the Field of Cornea
Researchers find proliferating cells in normal and diseased corneal endothelium

Researchers find proliferating cells in normal and diseased corneal endothelium

September 14, 2016

Findings published in the American Journal of Pathology offer new directions for treatment of patients with Fuchs’ Endothelial Corneal Dystrophy (FECD)

Boston, Mass. —  Researchers from Massachusetts Eye and Ear have, for the first time, identified rapidly proliferating cells (known as “neural crest-derived progenitor cells”) in the corneal endothelium of specimens from normal corneas and from corneas with Fuchs’ Endothelial Corneal Dystrophy (FECD), a condition in which the cells responsible for keeping the cornea...

Read more about Researchers find proliferating cells in normal and diseased corneal endothelium
Inflammatory Factors Cause Damage to Back of Eye Following Keratoprosthesis Implantation

Inflammatory Factors Cause Damage to Back of Eye Following Keratoprosthesis Implantation

April 7, 2016

Researchers at Massachusetts Eye and Ear/Harvard Medical School have identified inflammatory factors that contribute to optic nerve damage following keratoprosthesis (KPro) implantation in a mouse model. They have also shown that blocking one of the factors, TNFa, leads to a significant decrease in optic nerve cell death, suggesting a new direction for preventing optic nerve damage in patients with keratoprosthesis implants.

BOSTON – Researchers from...

Read more about Inflammatory Factors Cause Damage to Back of Eye Following Keratoprosthesis Implantation
New Research Links Mitochondrial Dysfunction to Development of Fuchs’ Endothelial Corneal Dystrophy (FECD), a Common Cause of Corneal Swelling and Blindness

New Research Links Mitochondrial Dysfunction to Development of Fuchs’ Endothelial Corneal Dystrophy (FECD), a Common Cause of Corneal Swelling and Blindness

March 7, 2016

Findings could eventually lead to first non-surgical therapies and treatments for FECD. 

BOSTON -- Researchers at Schepens Eye Research Institute of Massachusetts Eye and Ear have shown a link between mitochondrial dysfunction in corneal endothelial cells and the development of Fuchs’ Endothelial Corneal Dystrophy (FECD)....

Read more about New Research Links Mitochondrial Dysfunction to Development of Fuchs’ Endothelial Corneal Dystrophy (FECD), a Common Cause of Corneal Swelling and Blindness
The S-Stamp Eliminates the Primary Cause of Graft Failure in DMEK

The S-Stamp Eliminates the Primary Cause of Graft Failure in DMEK

January 26, 2016

Peter Veldman, MD, of Mass. Eye and Ear was first author on two recent publications related to the S-stamp for Descemet membrane endothelial keratoplasty (DMEK), a novel orientation technique that has to date eliminated upside-down graft implantation in DMEK. Dr. Veldman helped to validate and then successfully implement this technique over the last...

Read more about The S-Stamp Eliminates the Primary Cause of Graft Failure in DMEK

Press for Boston KPro

September 1, 2015

Mass. Eye and Ear's Boston KPro was credited as the most widely used artificial cornea in an article from Ophthalmology Times on the use of bioengineered corneas.

September 1, 2015 Ophthalmology Times

Researchers Regrow Human Corneas: First Known Tissue Grown from a Human Stem Cell

July 2, 2014

Limbal stem cells -- identified with a new marker -- could reverse a leading cause of blindness

BOSTON (July 2, 2014) -- Boston researchers have identified a way to enhance regrowth of human corneal tissue to restore vision, using a molecule known as ABCB5 that acts as a marker for hard-to-find limbal stem cells. This work, a collaboration between the Massachusetts Eye and Ear/Schepens Eye Research Institute (Mass. Eye and Ear), Boston Children’s Hospital, Brigham and Women’s Hospital and the VA Boston Healthcare System, provides...

Read more about Researchers Regrow Human Corneas: First Known Tissue Grown from a Human Stem Cell