A CRISPR View of Cleavage.


Weinberger AD, Gilmore MS. A CRISPR View of Cleavage. Cell 2015;161(5):964-6.

Date Published:

2015 May 21


Seminal studies showed that CRISPR-Cas systems provide adaptive immunity in prokaryotes and promising gene-editing tools from bacteria to humans. Yet, reports diverged on whether some CRISPR systems naturally target DNA or RNA. Here, Samai and colleagues unify the studies, showing that a single type III CRISPR-Cas system cleaves both DNA and RNA targets, independently.

Last updated on 11/19/2018